Effects of Tylosin and Nisin

Many antibiotics have been screened for inhibition of sporeforming bacteria during the last 10 years in this laboratory. The effect of some of these antibiotics on canned food spoilage bacteria has previously been described (Denny and Bohrer, 1959). Recently, two antibiotics which eventually may be of use in food processing have been through a preliminary screening in this laboratory. These antibiotics are nisin and tylosin. Nisin has been recommended for approval for use in certain foods in Great Britain (Her Majesty's Stationery Office, 1959). Our sample was obtained through the courtesy of Dr. H. B. Hawley of Alpin and Barrett, Ltd., Yoevil, Somerset, England. Tylosin is undergoing extensive animal toxicity tests in the manufacturer's laboratory. These are nearly complete and appear promising with respect to its suitability for use in food. Dr. Bernard Malin of Eli Lilly and Company in Indianapolis, Indiana, graciously supplied the sample for our tests.